CD 항원(CD1 ~ CD50)

HUMAN CD ANTIGENS CD1 TO CD10

Name	ｅxpression	MW	Function	Other Names
CD1a	cortical thymocytes, Langerhans cells, DC	49kD	antigen presentation, w/ β2m	T6
CD1b	cortical thymocytes, Langerhans cells, DC	45kD	antigen presentation, w/ β2m	T6
CD1c	cortical thymocytes, Langerhans cells, DC, B subset	43kD	antigen presentation, w/ β2m	T6
CD1d	intestinal epith, B subset, mono, DC	49kD	antigen presentation, w/ β2m
CD1e	DC	28kD	antigen presentation, w/ β2m
CD2	thymocytes, T, NK	50kD	CD58 ligand, adhesion, T cell activation	T11, LFA-2, SRBC-R
CD2R	Tact	50kD	activation-dependent form of CD2	T11-3
CD3gd	T, thymocyte subset		w/ TCR, TCR surface ｅxpression/signal transduction	T3
CD3e	T, thymocyte subset	20kD	w/ TCR, TCR surface ｅxpression/signal transduction	T3
CD4	thymocyte subset, T subset, mono, mac	55kD	MHC class II coreceptor, HIV receptor, T cell differentiation/activation	T4
CD5	thymocytes, T, B subset, B-CLL	67kD	CD72 receptor, TCR or BCR signaling, T-B interaction	T1, Tp67
CD6	thymocytes, T, B subset	100- 130kD	CD166 receptor, T cell differentiation/ costimulation	T12
CD7	hematopoietic progenitors, thymocytes, T, NK	40kD	T costimulation
CD8a	thymocyte subset, T subset, NK	32-34kD	MHC class I coreceptor, receptor for some mutated HIV-1, T cell differentiation/activation	T8, Leu-2
CD8b	thymocyte subset, T subset	30-32kD
CD9	pre-B, eosinophils, basophils, platelets, Tact	22-27kD	cellular adhesion and migration	p24, MRP-1
CD10	B precursors, T precursors, neutrophils	100kD	zinc-binding metalloproteinase, B cell development	CALLA, NEP, gp100

 

HUMAN CD ANTIGENS CD11 TO CD20

Name	ｅxpression	MW	Function	Other Names
CD11a	lymph, gran, mono, mac	180kD	CD11a/CD18 receptor for ICAM-1, -2,-3, intercellular adhesion, T costimulation	LFA-1, integrin αL
CD11b	myeloid cells, NK	170kD	binds CD54, ECM, iC3b	Mac-1, integrin αM
CD11c	DC, myeloid cells, NK, B, T subset	150kD	binds CD54, fibrinogen and iC3b	p150, 95, CR4, integrin αX
CDw12	mono, gran, platelets	90-120 kD
CD13	myeloid cells	150-170kD	zinc-binding metalloproteinase, antigen processing, receptor for corona virus strains	Aminopeptidase N, APN
CD14	mono, mac, Langerhans cells, granlow	53-55kD	receptor for LPS/LBP, LPS recognition	LPS-R
CD15	neutrophils, eosinophils, mono		adhesion	Lewis-x, Lex
CD15s	neutrophils, eosinophils, mono, memory helper T, and B, NK, HEV		CD62L and CD62P ligand, adhesion	Sialyl Lewis X
CD15u	myeloid subset		adhesion	Sulfated Lewis X
CD16a	neutrophils, mac, NK	50-65kD	component of low affinity Fc receptor, phagocytosis and ADCC	FcγRIIIA
CD16b	neutrophils	48kD	component of low affinity Fc receptor, phagocytosis and ADCC	FcγRIIIB
CDw17	neutrophils, mono, platelets		lactosyl ceramide
CD18	broad, all leukocytes	95kD	w/ CD11a, b &c, adhesion	Integrin β2
CD19	B, FDC	95kD	complex w/ CD21 and CD81, BCR coreceptor, B cell activation/ differentiation	B4
CD20	B, T subset	33-37kD	B cell activation	B1, Bp35

 

HUMAN CD ANTIGENS CD21 TO CD30

Name	ｅxpression	MW	Function	Other Names
CD21	B, FDC, T subset	145, 110kD	complement C3d and EBV receptor, complex w/ CD19 and CD81, BCR coreceptor	C3DR, CR2, EBV-R
CD22	B	150kD	adhesion, B-mono, B-T interactions	BL-CAM, Siglec-2
CD23	B, activated mac, eosinophils, FDC, platelets	45kD	CD19-CD21-CD81 receptor, IgE low affinity receptor, signal transduction	FcεRII
CD24	thymocytes, erythrocytes, peripheral lymph, myeloid	35-45 kD	binds P-selectin	BA-1
CD25	Tact, Bact, lymph progenitors	55kD	IL-2Rα, w/ IL-2Rβ and γ to form high affinity complex	Tac, p55
CD26	thymocyte subset, Tact, soluble form	110kD	dipeptidyl peptidase, T costimulation, HIV entry	DPP IV
CD27	medullary thymocytes, T, B subset, NK subset	50-55 kD	CD70 receptor, T costimulation	T14
CD28	most T, thymocytes, plasma cells	44kD	CD80, CD86 receptor, T costimulation	Tp44, T44
CD29	lymph, mono, granlow, platelets, mast cells, fibroblasts, endoth	130kD	w/ CD49a (VLA-1) receptor for VCAM-1, MAdCAM-1 and ECM	Integrin β1
CD30	Bact, T and NK , Reed-Sternberg cells, anaplastic large cell lymphoma	105- 120kD	CD153 receptor, lymph proliferation/ apoptosis	Ki-1

 

HUMAN CD ANTIGENS CD31 TO CD40

Name	ｅxpression	MW	Function	Other Names
CD31	mono, platelets, gran, endoth, lymph subset	130-140 kD	CD38 receptor, adhesion	PECAM-1
CD32	mono, gran, B, platelets	40kD	low affinity Fc receptor for aggregated Ig and immune complexes	FcγRII
CD33	myeloid progenitors, mono, gran, DC, mast cells, Tact	67kD	adhesion	p67, Siglec-3
CD34	hematopoietic precursors, capillary endoth, embryonic fibroblasts	105-120 kD	stem cell marker, adhesion, CD62L receptor
CD35	erythrocytes, B, mono, neutrophils, eosinophils, FDC, T subset	250kD	complement receptor 1, binds C3b and C4b, adhesion, phagocytosis	CR1
CD36	platelets, mono, mac, endoth, early erythrocytes	88kD	ECM receptor, adhesion, phagocytosis	GPIV
CD37	B, Tlow, granlow	40-52kD	signal transduction
CD38	variable levels on majority of hematopoietic cells, high ｅxpression on plasma cells, B and Tact	45kD	ecto-ADP-ribosyl cyclase, cell activation	T10
CD39	B cell adhesion, protects activated cells from lysis, ecto-apyrase	78kD
CD40	B, mono, mac, FDC, endoth, T subset	48kD	CD154 receptor, B differentiation / costimulation, isotype-switching, rescues B cells from apoptosis

 

HUMAN CD ANTIGENS CD41 TO CD50

Name	ｅxpression	MW	Function	Other Names
CD41	platelets, megakaryocytes	125/ 22kD	w/ CD61 forms GPIIb, binds fibrinogen, fibronectin, vWF, thrombospondin, platelet activation and aggregation	gpIIb
CD42a	platelets, megakaryocytes	22kD	complex w/ CD42b, c and d, receptor for vWF and thrombin, platelet adhesion to subendothelial matrices	GPIX
CD42b	platelets, megakaryocytes	145kD	complex w/ CD42a, c and d, binds to vWF and thrombin, platelet adhesion/ activation	GPIba
CD42c	platelets, megakaryocytes	24kD	complex w/ CD42a, b, d	GPIbb
CD42d	platelets, megakaryocytes	82kD	complex w/ CD42a-c	GPV
CD43	leukocytes, except resting B, plateletslow	115- 135kD	inhibition of T cell interaction, CD54R, adhesion	Leukosialin sialophorin
CD44	hematopoietic and non-hematopoietic cells, except platelets, hepatocytes, testis	80-95 kD	binds hyaluronic acid, adhesion	H-CAM, Pgp-1
CD44R	CD44 variants heterogeneous ｅxpression, constitutively on epith, mono, upregulated on activated leukocytes		adhesion, metastasis	CD44v
CD45	hematopoietic cells, multiple isoforms from alternative splicing	180- 240kD	tyrosine phosphatase, enhanced TCR &BCR signals	LCA, T200, B220
CD45RA	B, T subset(naive), mono	205- 220kD	exon A isoforms of CD45
CD45RB	T subset, B, mono, mac, gran	190- 220kD	exon B isoforms of CD45
CD45RO	Tact, memory T, B subset, mono, mac, gran	180kD	isoform of CD45 lacking A, B, C exons
CD46	nucleated cells	56/66 kD	membrane cofactor protein, binds C3b &C4b allowing degradation by Factor I, measles virus receptor	MCP
CD47	hematopoietic cells, epith, endoth, fibroblasts, other tissues	47-52 kD	leukocyte adhesion, migration, activation	IAP
CD47R	New designation for CDw149, similar distribution as CD47 but dimmer
CD48	broad, all leukocytes	45kD	cell adhesion	Blast-1
CD49a	Tact, mono	210kD	integrin α1, adhesion, CD49a /CD29 binds collagen and laminin	VLA-1
CD49b	B, mono, platelets, Tact, megakaryocytes	165kD	integrin α2, adhesion, CD49b /CD29 binds collagen and laminin	VLA-2
CD49c	B and Tlow, most adhesive cell lines	125kD	integrin α3, adhesion, CD49c /CD29 binds laminin, fibronectin and collagen	VLA-3
CD49d	T, B, NK, thymocytes, mono, eosinophils, mast, DC	150kD	integrin α4, adhesion, CD49d /CD29 binds fibronectin, VCAM-1 &MAdCAM-1	VLA-4
CD49e	thymocytes, T, mono, platelets, early and Bact	135, 25kD	integrin α5, adhesion, CD49e/CD29 binds fibronectin	VLA-5
CD49f	memory T, thymocytes, mono, platelets, megakaryocytes, epith	125kD	integrin α6, adhesion, CD49f/CD29 binds laminin	VLA-6
CD50	hematopoietic, endoth, epidermal Langerhans cells	110- 120kD	adhesion, costimulation	ICAM-3